Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer’s Disease Pathology

BACKGROUND: Previous studies suggest that Dickkopf-1 (DKK1), an inhibitor of Wnt signaling, plays a role in amyloid-induced toxicity and hence Alzheimer’s disease (AD). However, the effect of DKK1 expression on protein expression, and whether such proteins are altered in disease, is unknown. OBJECTI...

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Publicado en:J Alzheimers Dis
Autores principales: Shi, Liu, Winchester, Laura M., Liu, Benjamine Y., Killick, Richard, Ribe, Elena M., Westwood, Sarah, Baird, Alison L., Buckley, Noel J., Hong, Shengjun, Dobricic, Valerija, Kilpert, Fabian, Franke, Andre, Kiddle, Steven, Sattlecker, Martina, Dobson, Richard, Cuadrado, Antonio, Hye, Abdul, Ashton, Nicholas J., Morgan, Angharad R., Bos, Isabelle, Vos, Stephanie J.B., ten Kate, Mara, Scheltens, Philip, Vandenberghe, Rik, Gabel, Silvy, Meersmans, Karen, Engelborghs, Sebastiaan, De Roeck, Ellen E., Sleegers, Kristel, Frisoni, Giovanni B., Blin, Olivier, Richardson, Jill C., Bordet, Régis, Molinuevo, José L., Rami, Lorena, Wallin, Anders, Kettunen, Petronella, Tsolaki, Magda, Verhey, Frans, Lleó, Alberto, Alcolea, Daniel, Popp, Julius, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Johannsen, Peter, Teunissen, Charlotte E., Freund-Levi, Yvonne, Frölich, Lutz, Legido-Quigley, Cristina, Barkhof, Frederik, Blennow, Kaj, Rasmussen, Katrine Laura, Nordestgaard, Børge Grønne, Frikke-Schmidt, Ruth, Nielsen, Sune Fallgaard, Soininen, Hilkka, Vellas, Bruno, Kloszewska, Iwona, Mecocci, Patrizia, Zetterberg, Henrik, Morgan, B. Paul, Streffer, Johannes, Visser, Pieter Jelle, Bertram, Lars, Nevado-Holgado, Alejo J., Lovestone, Simon
Formato: Artigo
Lenguaje:Inglês
Publicado: IOS Press 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7683080/
https://ncbi.nlm.nih.gov/pubmed/32831200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-200208
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