Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer’s Disease Pathology

BACKGROUND: Previous studies suggest that Dickkopf-1 (DKK1), an inhibitor of Wnt signaling, plays a role in amyloid-induced toxicity and hence Alzheimer’s disease (AD). However, the effect of DKK1 expression on protein expression, and whether such proteins are altered in disease, is unknown. OBJECTI...

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Opis bibliograficzny
Wydane w:J Alzheimers Dis
Główni autorzy: Shi, Liu, Winchester, Laura M., Liu, Benjamine Y., Killick, Richard, Ribe, Elena M., Westwood, Sarah, Baird, Alison L., Buckley, Noel J., Hong, Shengjun, Dobricic, Valerija, Kilpert, Fabian, Franke, Andre, Kiddle, Steven, Sattlecker, Martina, Dobson, Richard, Cuadrado, Antonio, Hye, Abdul, Ashton, Nicholas J., Morgan, Angharad R., Bos, Isabelle, Vos, Stephanie J.B., ten Kate, Mara, Scheltens, Philip, Vandenberghe, Rik, Gabel, Silvy, Meersmans, Karen, Engelborghs, Sebastiaan, De Roeck, Ellen E., Sleegers, Kristel, Frisoni, Giovanni B., Blin, Olivier, Richardson, Jill C., Bordet, Régis, Molinuevo, José L., Rami, Lorena, Wallin, Anders, Kettunen, Petronella, Tsolaki, Magda, Verhey, Frans, Lleó, Alberto, Alcolea, Daniel, Popp, Julius, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Johannsen, Peter, Teunissen, Charlotte E., Freund-Levi, Yvonne, Frölich, Lutz, Legido-Quigley, Cristina, Barkhof, Frederik, Blennow, Kaj, Rasmussen, Katrine Laura, Nordestgaard, Børge Grønne, Frikke-Schmidt, Ruth, Nielsen, Sune Fallgaard, Soininen, Hilkka, Vellas, Bruno, Kloszewska, Iwona, Mecocci, Patrizia, Zetterberg, Henrik, Morgan, B. Paul, Streffer, Johannes, Visser, Pieter Jelle, Bertram, Lars, Nevado-Holgado, Alejo J., Lovestone, Simon
Format: Artigo
Język:Inglês
Wydane: IOS Press 2020
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7683080/
https://ncbi.nlm.nih.gov/pubmed/32831200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-200208
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