The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior

BACKGROUND: The regulation of protein synthesis is a critical step in gene expression, and its dysfunction is implicated in autism spectrum disorder (ASD). The eIF4E homologous protein (4EHP, also termed eIF4E2) binds to the mRNA 5′ cap to repress translation. The stability of 4EHP is maintained thr...

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Publicado en:Mol Autism
Main Authors: Wiebe, Shane, Meng, Xiang Qi, Kim, Sung-Hoon, Zhang, Xu, Lacaille, Jean-Claude, Aguilar-Valles, Argel, Sonenberg, Nahum
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682028/
https://ncbi.nlm.nih.gov/pubmed/33225984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00394-7
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