Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56(Lck) regulates T-cell activation independently of Lck/CD45 interactions

BACKGROUND: Upon engagement of the T-cell receptor (TCR), the Src-family protein tyrosine kinase p56Lck phosphorylates components of the TCR (e.g. the TCRζ chains), thereby initiating T-cell activation. The enzymatic activity of Lck is primarily regulated via reversible and dynamic phosphorylation o...

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Publicat a:Cell Commun Signal
Autors principals: Kästle, Matthias, Merten, Camilla, Hartig, Roland, Kaehne, Thilo, Liaunardy-Jopeace, Ardiyanto, Woessner, Nadine M., Schamel, Wolfgang W., James, John, Minguet, Susana, Simeoni, Luca, Schraven, Burkhart
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682018/
https://ncbi.nlm.nih.gov/pubmed/33225946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00673-z
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