K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway

BACKGROUND: Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative disorders characterized by gradual memory loss and neuropsychiatric symptoms. We have previously demonstrated that the 2-({3-[2-(1-cyclohexene-1-yl)ethyl]-6,7-dimethoxy-4-oxo-3,4-dihydro-2-quinazolinyl}sulfanyl)-N-(4...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Ham, Hyeon Joo, Lee, Yong Sun, Yun, Jaesuk, Son, Dong Ju, Lee, Hee Pom, Han, Sang-Bae, Hong, Jin Tae
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681957/
https://ncbi.nlm.nih.gov/pubmed/33222690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-02022-w
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