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Age‐induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge

Mitochondrial dysfunction is frequently associated with impairment in metabolic homeostasis and insulin action, and is thought to underlie cellular aging. However, it is unclear whether mitochondrial dysfunction is a cause or consequence of insulin resistance in humans. To determine the impact of in...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Moore, Timothy M., Zhou, Zhenqi, Strumwasser, Alexander R., Cohn, Whitaker, Lin, Amanda J., Cory, Kevin, Whitney, Kate, Ho, Theodore, Ho, Timothy, Lee, Joseph L., Rucker, Daniel H., Hoang, Austin N., Widjaja, Kevin, Abrishami, Aaron D., Charugundla, Sarada, Stiles, Linsey, Whitelegge, Julian P., Turcotte, Lorraine P., Wanagat, Jonathan, Hevener, Andrea L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681042/
https://ncbi.nlm.nih.gov/pubmed/33049094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13166
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