Age‐induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge

Mitochondrial dysfunction is frequently associated with impairment in metabolic homeostasis and insulin action, and is thought to underlie cellular aging. However, it is unclear whether mitochondrial dysfunction is a cause or consequence of insulin resistance in humans. To determine the impact of in...

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Vydáno v:Aging Cell
Hlavní autoři: Moore, Timothy M., Zhou, Zhenqi, Strumwasser, Alexander R., Cohn, Whitaker, Lin, Amanda J., Cory, Kevin, Whitney, Kate, Ho, Theodore, Ho, Timothy, Lee, Joseph L., Rucker, Daniel H., Hoang, Austin N., Widjaja, Kevin, Abrishami, Aaron D., Charugundla, Sarada, Stiles, Linsey, Whitelegge, Julian P., Turcotte, Lorraine P., Wanagat, Jonathan, Hevener, Andrea L.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681042/
https://ncbi.nlm.nih.gov/pubmed/33049094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13166
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