Age‐induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge

Mitochondrial dysfunction is frequently associated with impairment in metabolic homeostasis and insulin action, and is thought to underlie cellular aging. However, it is unclear whether mitochondrial dysfunction is a cause or consequence of insulin resistance in humans. To determine the impact of in...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Moore, Timothy M., Zhou, Zhenqi, Strumwasser, Alexander R., Cohn, Whitaker, Lin, Amanda J., Cory, Kevin, Whitney, Kate, Ho, Theodore, Ho, Timothy, Lee, Joseph L., Rucker, Daniel H., Hoang, Austin N., Widjaja, Kevin, Abrishami, Aaron D., Charugundla, Sarada, Stiles, Linsey, Whitelegge, Julian P., Turcotte, Lorraine P., Wanagat, Jonathan, Hevener, Andrea L.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681042/
https://ncbi.nlm.nih.gov/pubmed/33049094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13166
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