Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury

Podocyte injury is a critical step toward the progression of renal disease and is often associated with a loss of slit diaphragm proteins, including Podocin. Although there is a possibility that the extracellular domain of these slit diaphragm proteins can be a target for a pathological proteolysis,...

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Vydáno v:J Biol Chem
Hlavní autoři: Ozawa, Shota, Matsubayashi, Masaya, Nanaura, Hitoki, Yanagita, Motoko, Mori, Kiyoshi, Asanuma, Katsuhiko, Kajiwara, Nobuyuki, Hayashi, Kazuyuki, Ohashi, Hiroshi, Kasahara, Masato, Yokoi, Hideki, Kataoka, Hiroaki, Mori, Eiichiro, Nakagawa, Takahiko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681011/
https://ncbi.nlm.nih.gov/pubmed/32907879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013721
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