POISON EXON SPLICING REGULATES A COORDINATED NETWORK OF SR PROTEIN EXPRESSION DURING DIFFERENTIATION AND TUMORIGENESIS

The RNA isoform repertoire is regulated by splicing-factor (SF) expression, and alterations in SF-levels are associated with disease. SFs contain ultraconserved poison exon (PE) sequences, which exhibit greater identity across species than nearby coding exons, yet their physiological role and molecu...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Leclair, Nathan K., Brugiolo, Mattia, Urbanski, Laura, Lawson, Shane C., Thakar, Ketan, Yurieva, Marina, George, Joshy, Hinson, John Travis, Cheng, Albert, Graveley, Brenton R., Anczuków, Olga
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680420/
https://ncbi.nlm.nih.gov/pubmed/33176162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.10.019
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