PAF1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions with PHF5A and DDX3

BACKGROUND & AIMS: It is not clear how pancreatic cancer stem cells (CSCs) are regulated, resulting in ineffective treatments for pancreatic cancer. PAF1, a RNA polymerase II-associated factor 1 complex (PAF1C) component, maintains pluripotency of stem cells, by unclear mechanisms, and is a mark...

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Gepubliceerd in:Gastroenterology
Hoofdauteurs: Karmakar, Saswati, Rauth, Sanchita, Nallasamy, Palanisamy, Perumal, Naveenkumar, Nimmakalaya, Rama Krishna, Leon, Frank, Gupta, Rohitesh, Barkeer, Srikanth, Venkata, Ramakanth Chirravuri, Raman, Venu, Rachagani, Satyanarayana, Ponnusamy, Moorthy P., Batra, Surinder K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680365/
https://ncbi.nlm.nih.gov/pubmed/32781084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.07.053
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