Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes

Hypothalamic inflammation plays an important role in disrupting feeding behavior and energy homeostasis as well as in the pathogenesis of obesity and diabetes. Here, we show that pyruvate dehydrogenase kinase (PDK)-2 plays a role in hypothalamic inflammation and its sequelae in mouse models of diabe...

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Pubblicato in:Nat Commun
Autori principali: Rahman, Md Habibur, Bhusal, Anup, Kim, Jae-Hong, Jha, Mithilesh Kumar, Song, Gyun Jee, Go, Younghoon, Jang, Il-Sung, Lee, In-Kyu, Suk, Kyoungho
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680139/
https://ncbi.nlm.nih.gov/pubmed/33219201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19576-1
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