FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury

Autophagy of mitochondria, termed mitophagy, plays an important role in cerebral ischemia-reperfusion (IR) injury, but the mechanism is not yet clear. Tissue-type plasminogen activator (tPA) is the most important thrombolytic drug in the clinical treatment of ischemic stroke and has neuroprotective...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Redox Biol
Main Authors: Cai, Ying, Yang, Eryan, Yao, Xiuhua, Zhang, Xuebin, Wang, Qixue, Wang, Yunfei, Liu, Ji, Fan, Weijia, Yi, Kaikai, Kang, Chunsheng, Wu, Jialing
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679257/
https://ncbi.nlm.nih.gov/pubmed/33212415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101792
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