Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes

Pancreatic islet β-cell failure is key to the onset and progression of type 2 diabetes (T2D). The advent of single-cell RNA sequencing (scRNA-seq) has opened the possibility to determine transcriptional signatures specifically relevant for T2D at the β-cell level. Yet, applications of this technique...

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Библиографические подробности
Опубликовано в: :NAR Genom Bioinform
Главные авторы: Bosi, Emanuele, Marselli, Lorella, De Luca, Carmela, Suleiman, Mara, Tesi, Marta, Ibberson, Mark, Eizirik, Decio L, Cnop, Miriam, Marchetti, Piero
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
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Standard Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679065/
https://ncbi.nlm.nih.gov/pubmed/33575641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nargab/lqaa097
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