Targeting the PD-1/PD-L1 Axis in Human Vitiligo

Autoreactive CD8(+) T cells play a pivotal role in melanocyte destruction in autoimmune vitiligo. Immunotherapy for melanoma often leads to autoimmune side-effects, among which vitiligo-like depigmentation, indicating that targeting immune checkpoints can break peripheral tolerance against self-anti...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Willemsen, Marcella, Melief, Cornelis J. M., Bekkenk, Marcel W., Luiten, Rosalie M.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677560/
https://ncbi.nlm.nih.gov/pubmed/33240267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.579022
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