Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed as therapeutics and are a major contributor to neutralizing antibody responses elicited by infection. Here, we describe a deep mutational scanning method to map how all amino-acid mutations in the RBD affect...

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Pubblicato in:Cell Host Microbe
Autori principali: Greaney, Allison J., Starr, Tyler N., Gilchuk, Pavlo, Zost, Seth J., Binshtein, Elad, Loes, Andrea N., Hilton, Sarah K., Huddleston, John, Eguia, Rachel, Crawford, Katharine H.D., Dingens, Adam S., Nargi, Rachel S., Sutton, Rachel E., Suryadevara, Naveenchandra, Rothlauf, Paul W., Liu, Zhuoming, Whelan, Sean P.J., Carnahan, Robert H., Crowe, James E., Bloom, Jesse D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7676316/
https://ncbi.nlm.nih.gov/pubmed/33259788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.11.007
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