Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed as therapeutics and are a major contributor to neutralizing antibody responses elicited by infection. Here, we describe a deep mutational scanning method to map how all amino-acid mutations in the RBD affect...

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Bibliografski detalji
Izdano u:Cell Host Microbe
Glavni autori: Greaney, Allison J., Starr, Tyler N., Gilchuk, Pavlo, Zost, Seth J., Binshtein, Elad, Loes, Andrea N., Hilton, Sarah K., Huddleston, John, Eguia, Rachel, Crawford, Katharine H.D., Dingens, Adam S., Nargi, Rachel S., Sutton, Rachel E., Suryadevara, Naveenchandra, Rothlauf, Paul W., Liu, Zhuoming, Whelan, Sean P.J., Carnahan, Robert H., Crowe, James E., Bloom, Jesse D.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7676316/
https://ncbi.nlm.nih.gov/pubmed/33259788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.11.007
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