Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike (S) protein receptor-binding domain and block virus interactions with the cellular receptor angiotensin-converting enzyme 2. We describe a panel of human mAbs binding to diverse epitopes on the N-terminal domain (NTD...

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Publicado no:bioRxiv
Main Authors: Suryadevara, Naveenchandra, Shrihari, Swathi, Gilchuk, Pavlo, VanBlargan, Laura A., Binshtein, Elad, Zost, Seth J., Nargi, Rachel S., Sutton, Rachel E., Winkler, Emma S., Chen, Elaine C., Fouch, Mallorie E., Davidson, Edgar, Doranz, Benjamin J., Carnahan, Robert H., Thackray, Larissa B., Diamond, Michael S., Crowe, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7836115/
https://ncbi.nlm.nih.gov/pubmed/33501445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.19.427324
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