Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike (S) protein receptor-binding domain and block virus interactions with the cellular receptor angiotensin-converting enzyme 2. We describe a panel of human mAbs binding to diverse epitopes on the N-terminal domain (NTD...

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Bibliografske podrobnosti
izdano v:bioRxiv
Main Authors: Suryadevara, Naveenchandra, Shrihari, Swathi, Gilchuk, Pavlo, VanBlargan, Laura A., Binshtein, Elad, Zost, Seth J., Nargi, Rachel S., Sutton, Rachel E., Winkler, Emma S., Chen, Elaine C., Fouch, Mallorie E., Davidson, Edgar, Doranz, Benjamin J., Carnahan, Robert H., Thackray, Larissa B., Diamond, Michael S., Crowe, James E.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory 2021
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7836115/
https://ncbi.nlm.nih.gov/pubmed/33501445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.19.427324
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