Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike (S) protein receptor-binding domain and block virus interactions with the cellular receptor angiotensin-converting enzyme 2. We describe a panel of human mAbs binding to diverse epitopes on the N-terminal domain (NTD...

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Pubblicato in:bioRxiv
Autori principali: Suryadevara, Naveenchandra, Shrihari, Swathi, Gilchuk, Pavlo, VanBlargan, Laura A., Binshtein, Elad, Zost, Seth J., Nargi, Rachel S., Sutton, Rachel E., Winkler, Emma S., Chen, Elaine C., Fouch, Mallorie E., Davidson, Edgar, Doranz, Benjamin J., Carnahan, Robert H., Thackray, Larissa B., Diamond, Michael S., Crowe, James E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7836115/
https://ncbi.nlm.nih.gov/pubmed/33501445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.19.427324
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