Radiation-Induced Damage to Prepubertal Pax7+ Skeletal Muscle Stem Cells Drives Lifelong Deficits in Myofiber Size and Nuclear Number

During prepubertal development, muscle stem cells (satellite cells, SCs) actively contribute to myofiber growth. Because some SCs are active during this time, they may be particularly susceptible to damage. Using a Small Animal Radiation Research Platform (SARRP), we investigated the effects of loca...

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Veröffentlicht in:iScience
Hauptverfasser: Bachman, John F., Blanc, Roméo S., Paris, Nicole D., Kallenbach, Jacob G., Johnston, Carl J., Hernady, Eric, Williams, Jacqueline P., Chakkalakal, Joe V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674517/
https://ncbi.nlm.nih.gov/pubmed/33241204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101760
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