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Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion
HIV viremia can be controlled by chronic antiretroviral therapy. As a potentially single-shot alternative, B cells engineered by CRISPR/Cas9 to express anti-HIV broadly neutralizing antibodies (bNAbs) are capable of secreting high antibody titers. Here, we show that, upon immunization of mice, adopt...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7673991/ https://ncbi.nlm.nih.gov/pubmed/33203857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19649-1 |
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