Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion

HIV viremia can be controlled by chronic antiretroviral therapy. As a potentially single-shot alternative, B cells engineered by CRISPR/Cas9 to express anti-HIV broadly neutralizing antibodies (bNAbs) are capable of secreting high antibody titers. Here, we show that, upon immunization of mice, adopt...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Nat Commun
Main Authors: Nahmad, Alessio D., Raviv, Yuval, Horovitz-Fried, Miriam, Sofer, Ilan, Akriv, Tal, Nataf, Daniel, Dotan, Iris, Carmi, Yaron, Burstein, David, Wine, Yariv, Benhar, Itai, Barzel, Adi
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673991/
https://ncbi.nlm.nih.gov/pubmed/33203857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19649-1
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla