LRRK2 mediates tubulation and vesicle sorting from lysosomes

Genetic variation around the LRRK2 gene affects risk of both familial and sporadic Parkinson’s disease (PD). However, the biological functions of LRRK2 remain incompletely understood. Here, we report that LRRK2 is recruited to lysosomes after exposure of cells to the lysosome membrane–rupturing agen...

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Udgivet i:Sci Adv
Main Authors: Bonet-Ponce, Luis, Beilina, Alexandra, Williamson, Chad D., Lindberg, Eric, Kluss, Jillian H., Saez-Atienzar, Sara, Landeck, Natalie, Kumaran, Ravindran, Mamais, Adamantios, Bleck, Christopher K. E., Li, Yan, Cookson, Mark R.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673727/
https://ncbi.nlm.nih.gov/pubmed/33177079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb2454
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