Redox-responsive nanoplatform for codelivery of miR-519c and gemcitabine for pancreatic cancer therapy

Desmoplastic and hypoxic pancreatic cancer microenvironment induces aberrant expression of miRNAs and hypoxia-inducible factor-1α (HIF-1α) responsible for gemcitabine (GEM) resistance. We demonstrated that miR-519c was down-regulated in pancreatic cancer and transfection of miR-519c in GEM-resistant...

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Publicat a:Sci Adv
Autors principals: Xin, Xiaofei, Kumar, Virender, Lin, Feng, Kumar, Vinod, Bhattarai, Rajan, Bhatt, Vijaya R., Tan, Chalet, Mahato, Ram I.
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673723/
https://ncbi.nlm.nih.gov/pubmed/33177098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd6764
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