Codelivery of Small Molecule Hedgehog Inhibitor and miRNA for Treating Pancreatic Cancer

Successful treatment of pancreatic ductal adenocarcinoma (PDAC) remains a challenge due to the desmoplastic microenvironment that promotes both tumor growth and metastasis and forms a barrier to chemotherapy. Hedgehog (Hh) signaling is implicated in initiation and progression of PDAC and also contri...

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Bibliographic Details
Published in:Mol Pharm
Main Authors: Kumar, Virender, Mondal, Goutam, Slavik, Paige, Rachagani, Satyanarayna, Batra, Surinder K., Mahato, Ram I.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829351/
https://ncbi.nlm.nih.gov/pubmed/25679326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500847s
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