Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy

Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary for the synthesis of glycerolipids, interacts with...

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Publicado en:Nat Commun
Main Authors: Song, Lintao, Liu, Zhihua, Hu, Hui-Hui, Yang, Ying, Li, Terytty Yang, Lin, Zhi-Zhong, Ye, Jing, Chen, Jianing, Huang, Xi, Liu, Dong-Tai, Zhou, Jing, Shi, Yiran, Zhao, Hao, Xie, Changchuan, Chen, Lanfen, Song, Erwei, Lin, Shu-Yong, Lin, Sheng-Cai
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7672079/
https://ncbi.nlm.nih.gov/pubmed/33203880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19694-w
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