Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate

Obesity is characterized by excessive fatty acid conversion to triacylglycerols (TAGs) in adipose tissues. However, how signaling networks sense fatty acids and connect to the stimulation of lipid synthesis remains elusive. Here, we show that homozygous knock-in mice carrying a point mutation at the...

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Publicado no:Nat Commun
Main Authors: Li, Terytty Yang, Song, Lintao, Sun, Yu, Li, Jingyi, Yi, Cong, Lam, Sin Man, Xu, Dijin, Zhou, Linkang, Li, Xiaotong, Yang, Ying, Zhang, Chen-Song, Xie, Changchuan, Huang, Xi, Shui, Guanghou, Lin, Shu-Yong, Reue, Karen, Lin, Sheng-Cai
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953937/
https://ncbi.nlm.nih.gov/pubmed/29765047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04363-w
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