Genetic background influences expression and function of the cation channel TRPM4 in the mouse heart

Transient receptor potential melastatin 4 (TRPM4) cation channels act in cardiomyocytes as a negative modulator of the L-type Ca(2+) current. Ubiquitous Trpm4 deletion in mice leads to an increased β-adrenergic inotropy in healthy mice as well as after myocardial infarction. In this study, we set ou...

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Bibliografiske detaljer
Udgivet i:Basic Res Cardiol
Main Authors: Medert, Rebekka, Pironet, Andy, Bacmeister, Lucas, Segin, Sebastian, Londoño, Juan E. Camacho, Vennekens, Rudi, Freichel, Marc
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2020
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Original Contribution
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7671982/
https://ncbi.nlm.nih.gov/pubmed/33205255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-020-00831-x
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