Cardiomyocyte-Specific Deletion of Orai1 Reveals Its Protective Role in Angiotensin-II-Induced Pathological Cardiac Remodeling

Pathological cardiac remodeling correlates with chronic neurohumoral stimulation and abnormal Ca(2+) signaling in cardiomyocytes. Store-operated calcium entry (SOCE) has been described in adult and neonatal murine cardiomyocytes, and Orai1 proteins act as crucial ion-conducting constituents of this...

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Publicado en:Cells
Main Authors: Segin, Sebastian, Berlin, Michael, Richter, Christin, Medert, Rebekka, Flockerzi, Veit, Worley, Paul, Freichel, Marc, Camacho Londoño, Juan E.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290784/
https://ncbi.nlm.nih.gov/pubmed/32354146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9051092
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