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Compensated Hydroxyl Radical Protein Footprinting Measures Buffer and Excipient Effects on Conformation and Aggregation in an Adalimumab Biosimilar
Unlike small molecule drugs, therapeutic proteins must maintain the proper higher order structure (HOS) in order to maintain safety and efficacy. Due to the sensitivity of many protein systems, even small changes due to differences in protein expression or formulation can alter HOS. Previous work ha...
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| Udgivet i: | AAPS J |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7670911/ https://ncbi.nlm.nih.gov/pubmed/31297623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-019-0358-2 |
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