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Conformational Analysis of Therapeutic Proteins by Hydroxyl Radical Protein Footprinting

Unlike small molecule drugs, therapeutic protein pharmaceuticals must not only have the correct amino acid sequence and modifications, but also the correct conformation to ensure safety and efficacy. Here, we describe a method for comparison of therapeutic protein conformations by hydroxyl radical p...

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Autors principals: Watson, Caroline, Sharp, Joshua S.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326162/
https://ncbi.nlm.nih.gov/pubmed/22382679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9336-7
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