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Conformational Analysis of Therapeutic Proteins by Hydroxyl Radical Protein Footprinting
Unlike small molecule drugs, therapeutic protein pharmaceuticals must not only have the correct amino acid sequence and modifications, but also the correct conformation to ensure safety and efficacy. Here, we describe a method for comparison of therapeutic protein conformations by hydroxyl radical p...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer US
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326162/ https://ncbi.nlm.nih.gov/pubmed/22382679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9336-7 |
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