Compensated Hydroxyl Radical Protein Footprinting Measures Buffer and Excipient Effects on Conformation and Aggregation in an Adalimumab Biosimilar

Unlike small molecule drugs, therapeutic proteins must maintain the proper higher order structure (HOS) in order to maintain safety and efficacy. Due to the sensitivity of many protein systems, even small changes due to differences in protein expression or formulation can alter HOS. Previous work ha...

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Detaylı Bibliyografya
Yayımlandı:AAPS J
Asıl Yazarlar: Misra, Sandeep K., Orlando, Ron, Weinberger, Scot R., Sharp, Joshua S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670911/
https://ncbi.nlm.nih.gov/pubmed/31297623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-019-0358-2
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