Gene duplication, rather than epigenetic changes, drives FGF4 overexpression in KIT/PDGFRA/SDH/RAS-P WT GIST

Gastrointestinal stromal tumours that are wild type for KIT and PDGFRA are referred to as WT GISTs. Of these tumours, SDH-deficient (characterized by the loss of SDHB) and quadruple WT GIST (KIT/PDGFRA/SDH/RAS-P WT) subgroups were reported to display a marked overexpression of FGF4, identifying a pu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Urbini, Milena, Astolfi, Annalisa, Indio, Valentina, Nannini, Margherita, Schipani, Angela, Bacalini, Maria Giulia, Angelini, Sabrina, Ravegnini, Gloria, Calice, Giovanni, Del Gaudio, Massimo, Secchiero, Paola, Ulivi, Paola, Gruppioni, Elisa, Pantaleo, Maria Abbondanza
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670422/
https://ncbi.nlm.nih.gov/pubmed/33199729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76519-y
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge