Gene duplication, rather than epigenetic changes, drives FGF4 overexpression in KIT/PDGFRA/SDH/RAS-P WT GIST

Gastrointestinal stromal tumours that are wild type for KIT and PDGFRA are referred to as WT GISTs. Of these tumours, SDH-deficient (characterized by the loss of SDHB) and quadruple WT GIST (KIT/PDGFRA/SDH/RAS-P WT) subgroups were reported to display a marked overexpression of FGF4, identifying a pu...

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Udgivet i:Sci Rep
Main Authors: Urbini, Milena, Astolfi, Annalisa, Indio, Valentina, Nannini, Margherita, Schipani, Angela, Bacalini, Maria Giulia, Angelini, Sabrina, Ravegnini, Gloria, Calice, Giovanni, Del Gaudio, Massimo, Secchiero, Paola, Ulivi, Paola, Gruppioni, Elisa, Pantaleo, Maria Abbondanza
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670422/
https://ncbi.nlm.nih.gov/pubmed/33199729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76519-y
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