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The PWWP2A Histone Deacetylase Complex Represses Intragenic Spurious Transcription Initiation in mESCs

Transcriptional fidelity depends on accurate promoter selection and initiation from the correct sites. In yeast, H3K36me3-mediated recruitment of the Rpd3S HDAC complex to gene bodies suppresses spurious transcription initiation. Here we describe an equivalent pathway in metazoans. PWWP2A/B is an H3...

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Bibliografske podrobnosti
izdano v:iScience
Main Authors: Wei, Guifeng, Brockdorff, Neil, Zhang, Tianyi
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670215/
https://ncbi.nlm.nih.gov/pubmed/33235983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101741
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