Steroid sulfatase stimulates intracrine androgen synthesis and is a therapeutic target for advanced prostate cancer

PURPOSE: Most prostate cancer patients receiving enzalutamide or abiraterone develop resistance. Clinical evidence indicates that serum levels of dehydroepiandrosterone sulfate (DHEAS) and biologically active dehydroepiandrosterone (DHEA) remain in the high range despite anti-androgen treatment. The...

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Foilsithe in:Clin Cancer Res
Main Authors: Armstrong, Cameron M., Liu, Chengfei, Liu, Liangren, Yang, Joy C., Lou, Wei, Zhao, Ruining, Ning, Shu, Lombard, Alan P., Zhao, Jinge, D’Abronzo, Leandro S, Evans, Christopher P., Li, Pui-Kai, Gao, Allen C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7669645/
https://ncbi.nlm.nih.gov/pubmed/32928794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-1682
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