AKR1C3 promotes AR-V7 protein stabilization and confers resistance to AR-targeted therapies in advanced prostate cancer

The mechanisms resulting in resistance to next generation anti-androgens in castration resistant prostate cancer are incompletely understood. Numerous studies have determined that constitutively active androgen receptor (AR) signaling or full length AR bypass mechanisms may contribute to the resista...

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Publicado en:Mol Cancer Ther
Main Authors: Liu, Chengfei, Yang, Joy C., Armstrong, Cameron M., Lou, Wei, Liu, Liangren, Qiu, Xiaomin, Zou, Binhao, Lombard, Alan P., D’Abronzo, Leandro S, Evans, Christopher P., Gao, Allen C.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995728/
https://ncbi.nlm.nih.gov/pubmed/31308078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1322
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