Multiplex immunofluorescence in formalin-fixed paraffin-embedded tumor tissue to identify single cell-level PI3K pathway activation

PURPOSE: Identifying cancers with high PI3K pathway activity is critical for treatment selection and eligibility into clinical trials of PI3K inhibitors. Assessments of tumor signaling pathway activity need to consider intratumoral heterogeneity and multiple regulatory nodes. METHODS: We established...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Stopsack, Konrad H., Huang, Ying, Tyekucheva, Svitlana, Gerke, Travis A., Bango, Clyde, Elfandy, Habiba, Bowden, Michaela, Penney, Kathryn L., Roberts, Thomas M., Parmigiani, Giovanni, Kantoff, Philip W., Mucci, Lorelei A., Loda, Massimo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7669556/
https://ncbi.nlm.nih.gov/pubmed/32913135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2000
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