Identification of a unique TCR repertoire, consistent with a superantigen selection process in Children with Multi-system Inflammatory Syndrome

Multisystem Inflammatory Syndrome in Children (MIS-C), a hyperinflammatory syndrome associated with SARS-CoV-2 infection, shares many clinical features with toxic shock syndrome, which is triggered by bacterial superantigens. The superantigen specificity for binding different Vβ-chains results in Vβ...

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izdano v:bioRxiv
Main Authors: Porritt, Rebecca A, Paschold, Lisa, Noval Rivas, Magali, Hongying Cheng, Mary, Yonker, Lael M, Chandnani, Harsha, Lopez, Merrick, Simnica, Donjete, Schultheiß, Christoph, Santiskulvong, Chintda, Van Eyk, Jennifer, Fasano, Alessio, Bahar, Ivet, Binder, Mascha, Arditi, Moshe
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668738/
https://ncbi.nlm.nih.gov/pubmed/33200133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.09.372169
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