Identification of a unique TCR repertoire, consistent with a superantigen selection process in Children with Multi-system Inflammatory Syndrome

Multisystem Inflammatory Syndrome in Children (MIS-C), a hyperinflammatory syndrome associated with SARS-CoV-2 infection, shares many clinical features with toxic shock syndrome, which is triggered by bacterial superantigens. The superantigen specificity for binding different Vβ-chains results in Vβ...

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Publicat a:bioRxiv
Autors principals: Porritt, Rebecca A, Paschold, Lisa, Noval Rivas, Magali, Hongying Cheng, Mary, Yonker, Lael M, Chandnani, Harsha, Lopez, Merrick, Simnica, Donjete, Schultheiß, Christoph, Santiskulvong, Chintda, Van Eyk, Jennifer, Fasano, Alessio, Bahar, Ivet, Binder, Mascha, Arditi, Moshe
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668738/
https://ncbi.nlm.nih.gov/pubmed/33200133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.09.372169
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