Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity

Manganese (Mn)-induced neurotoxicity resembles Parkinson's disease (PD), but the mechanisms underpinning its effects remain unknown. Mn dysregulates astrocytic glutamate transporters, GLT-1 and GLAST, and dopaminergic function, including tyrosine hydroxylase (TH). Our previous in vitro studies...

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Vydáno v:J Biol Chem
Hlavní autoři: Pajarillo, Edward, Johnson, James, Rizor, Asha, Nyarko-Danquah, Ivan, Adinew, Getinet, Bornhorst, Julia, Stiboller, Michael, Schwerdtle, Tania, Son, Deok-Soo, Aschner, Michael, Lee, Eunsook
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667968/
https://ncbi.nlm.nih.gov/pubmed/32893191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015552
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