Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction

Microglia are the principal phagocytes that clear cell debris in the central nervous system (CNS). This raises the question, which cells remove cell debris when microglial phagocytic activity is impaired. We addressed this question using Siglech (dtr) mice, which enable highly specific ablation of m...

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Pubblicato in:EMBO J
Autori principali: Konishi, Hiroyuki, Okamoto, Takayuki, Hara, Yuichiro, Komine, Okiru, Tamada, Hiromi, Maeda, Mitsuyo, Osako, Fumika, Kobayashi, Masaaki, Nishiyama, Akira, Kataoka, Yosky, Takai, Toshiyuki, Udagawa, Nobuyuki, Jung, Steffen, Ozato, Keiko, Tamura, Tomohiko, Tsuda, Makoto, Yamanaka, Koji, Ogi, Tomoo, Sato, Katsuaki, Kiyama, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667883/
https://ncbi.nlm.nih.gov/pubmed/32959911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104464
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