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EGFR‐mediated tyrosine phosphorylation of STING determines its trafficking route and cellular innate immunity functions
STING (STimulator of INterferon Genes) mediates protective cellular response to microbial infection and tissue damage, but its aberrant activation can lead to autoinflammatory diseases. Upon ligand stimulation, the endoplasmic reticulum (ER) protein STING translocates to endosomes for induction of i...
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| Udgivet i: | EMBO J |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7667877/ https://ncbi.nlm.nih.gov/pubmed/32926474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019104106 |
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