Enhanced differentiation of human pluripotent stem cells into pancreatic endocrine cells in 3D culture by inhibition of focal adhesion kinase

BACKGROUND: Generation of insulin-producing cells from human pluripotent stem cells (hPSCs) in vitro would be useful for drug discovery and cell therapy in diabetes. Three-dimensional (3D) culture is important for the acquisition of mature insulin-producing cells from hPSCs, but the mechanism by whi...

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Veröffentlicht in:Stem Cell Res Ther
Hauptverfasser: Liu, Xiaofang, Qin, Jinhua, Chang, Mingyang, Wang, Shuyong, Li, Yali, Pei, Xuetao, Wang, Yunfang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667734/
https://ncbi.nlm.nih.gov/pubmed/33198821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-02003-z
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