Inhibitors of Src and Focal Adhesion Kinase Promote Endocrine Specification: IMPACT ON THE DERIVATION OF β-CELLS FROM HUMAN PLURIPOTENT STEM CELLS

Stepwise approaches for the derivation of β-cells from human embryonic stem cells have been described. However, low levels of endocrine specification limit the final yield of insulin-producing β-cells. In this study, we show that the pyrrolo-pyrimidine Src family kinase (SFK) inhibitor PP2 effective...

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Detalhes bibliográficos
Main Authors: Afrikanova, Ivka, Yebra, Mayra, Simpkinson, Megan, Xu, Yang, Hayek, Alberto, Montgomery, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195622/
https://ncbi.nlm.nih.gov/pubmed/21852242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.290825
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