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Src SH2 Arginine 175 Is Required for Cell Motility: Specific Focal Adhesion Kinase Targeting and Focal Adhesion Assembly Function

Src kinase is a crucial mediator of adhesion-related signaling and motility. Src binds to focal adhesion kinase (FAK) through its SH2 domain and subsequently activates it for phosphorylation of downstream substrates. In addition to this binding function, data suggested that the SH2 domain might also...

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Main Authors: Yeo, Myeong Gu, Partridge, Michael A., Ezratty, Ellen J., Shen, Qiong, Gundersen, Gregg G., Marcantonio, Eugene E.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489135/
https://ncbi.nlm.nih.gov/pubmed/16738308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01147-05
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