Apigenin Inhibits NNK-induced Focal Adhesion Kinase Activation in Pancreatic Cancer Cells

OBJECTIVES: Tobacco-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, NNK, activates β-adrenergic receptor (β-AR) signaling through Src/focal adhesion kinases (FAK)/MAPK to modulate proliferation, migration and survival. Apigenin (4′, 5, 7-trihydroxyflavone) is reported to attenuate...

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Main Authors: Pham, Hung, Chen, Monica, Takahashi, Hiroki, King, Jonathan, Reber, Howard A., Hines, Oscar Joe, Pandol, Stephen, Eibl, Guido
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479318/
https://ncbi.nlm.nih.gov/pubmed/22889981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0b013e31824d64d9
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