Development and Validation of UHPLC-MS/MS Assay for Therapeutic Drug Monitoring of High-dose Methotrexate in Children with Acute Lymphoblastic Leukemia

PURPOSE: Precise and timely detection of methotrexate (MTX) concentration played a key role in high-dose MTX individualization therapy in acute lymphoblastic leukemia (ALL) children to avoid serious adverse effects or nonresponse. This report described a sensibility and validation of ultra-high perf...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Lian, Le-jing, Lin, Bin, Cui, Xiao, He, Jie, Wang, Zhe, Lin, Xiao-dong, Ye, Wei-jian, Chen, Rui-jie, Sun, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667408/
https://ncbi.nlm.nih.gov/pubmed/33204069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S271568
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