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Determination of Anlotinib, a Tyrosine Kinase Inhibitor, in Rat Plasma by UHPLC-MS/MS and Its Application to a Pharmacokinetic Study

Anlotinib is a novel inhibitor of receptor kinase tyrosine with multitargets and has a broad spectrum of inhibitory action on tumor angiogenesis and growth. A simple and rapid UHPLC-MS/MS bioanalytical method was validated for the determination of anlotinib in rat plasma, using imatinib as an intern...

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Detalhes bibliográficos
Publicado no:J Anal Methods Chem
Main Authors: Wang, Zhe, Lian, Le-jing, Dong, Yan-yan, Cui, Xiao, Qian, Jian-chang, Huang, Cheng-ke, Chen, Rui-jie, Sun, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925768/
https://ncbi.nlm.nih.gov/pubmed/31886022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/5016757
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