Maternal sitagliptin treatment attenuates offspring glucose metabolism and intestinal proinflammatory cytokines IL-6 and TNF-α expression in male rats

Increasing evidence shows that maternal overnutrition may increase the risk of diabetes in offspring. We hypothesized that maternal sitagliptin intervention may improve glucose intolerance through gut targeting. Female Sprague-Dawley (SD) rats were fed a normal diet (ND) or a high-fat diet (HFD) for...

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Vydáno v:PeerJ
Hlavní autoři: Zhang, Qian, Xiao, Xinhua, Zheng, Jia, Li, Ming, Yu, Miao, Ping, Fan, Wang, Tong, Wang, Xiaojing
Médium: Artigo
Jazyk:Inglês
Vydáno: PeerJ Inc. 2020
Témata:
Diabetes and Endocrinology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666563/
https://ncbi.nlm.nih.gov/pubmed/33240638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.10310
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