Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis

Transcription of SARS-CoV-2 mRNA requires sequential reactions facilitated by the replication and transcription complex (RTC). Here, we present a structural snapshot of SARS-CoV-2 RTC as it transitions toward cap structure synthesis. We determine the atomic cryo-EM structure of an extended RTC assem...

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Veröffentlicht in:Cell
Hauptverfasser: Yan, Liming, Ge, Ji, Zheng, Litao, Zhang, Ying, Gao, Yan, Wang, Tao, Huang, Yucen, Yang, Yunxiang, Gao, Shan, Li, Mingyu, Liu, Zhenyu, Wang, Haofeng, Li, Yingjian, Chen, Yu, Guddat, Luke W., Wang, Quan, Rao, Zihe, Lou, Zhiyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Inc. 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666536/
https://ncbi.nlm.nih.gov/pubmed/33232691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.11.016
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