Coupling of N7-methyltransferase and 3′-5′ exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading

The capping of mRNA and the proofreading play essential roles in SARS-CoV-2 replication and transcription. Here, we present the cryo-EM structure of the SARS-CoV-2 replication-transcription complex (RTC) in a form identified as Cap(0)-RTC, which couples a co-transcriptional capping complex (CCC) com...

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Veröffentlicht in:Cell
Hauptverfasser: Yan, Liming, Yang, Yunxiang, Li, Mingyu, Zhang, Ying, Zheng, Litao, Ge, Ji, Huang, Yucen C., Liu, Zhenyu, Wang, Tao, Gao, Shan, Zhang, Ran, Huang, Yuanyun Y., Guddat, Luke W., Gao, Yan, Rao, Zihe, Lou, Zhiyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Inc. 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8142856/
https://ncbi.nlm.nih.gov/pubmed/34143953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.05.033
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