Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Domain

Mosquito inoculation of humans with arthritogenic alphaviruses results in a febrile syndrome characterized by debilitating musculoskeletal pain and arthritis. Despite an expanding global disease burden, no approved therapies or licensed vaccines exist. Here, we describe human monoclonal antibodies (...

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Gepubliceerd in:Cell Host Microbe
Hoofdauteurs: Powell, Laura A., Miller, Andrew, Fox, Julie M., Kose, Nurgun, Klose, Thomas, Kim, Arthurs S., Bombardi, Robin, Tennekoon, Rashika N., de Silva, A. Dharshan, Carnahan, Robert H., Diamond, Michael S., Rossmann, Michael G., Kuhn, Richard J., Crowe, James E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666055/
https://ncbi.nlm.nih.gov/pubmed/32783883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.07.008
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